Definition, Meaning & Synonyms

upregulate

verb

/ˌʌpˈrɛɡ.jʊ.leɪt/

Definition

To increase the expression or activity of a gene, protein, or cellular pathway in response to certain stimuli.

Examples

Cells may upregulate specific receptors in response to hormone levels.
This drug works by upregulating the genes involved in cell growth.
The immune system can upregulate certain markers to improve its response to infections.

Meaning

In biology and genetics, upregulation refers to the process whereby a cell increases the quantity of a cellular component, such as RNA or protein, in response to an external signal. This can enhance the function of that component within a biological pathway.