Definition, Meaning & Synonyms

downregulate

verb

/ˈdaʊnˌrɛɡ.jʊ.leɪt/

Definition

To decrease the activity or expression of a specific gene, protein, or biological pathway in a cell or organism.

Examples

The body can downregulate certain receptors in response to increased hormone levels.
Researchers found that the drug can downregulate the expression of inflammatory genes.
Downregulating the production of specific proteins may help in controlling cell growth.

Meaning

Downregulation refers to the process by which a cell reduces the quantity or activity of a molecular component, such as a receptor or enzyme, often in response to external stimuli or changes in the environment.