What Types of Molecules Move by Simple Diffusion, Facilitated Diffusion, and Active Transport?

Different types of molecules move across cell membranes through various mechanisms, including simple diffusion, facilitated diffusion, and active transport. Here’s a breakdown of the types of molecules that use each method:

Simple Diffusion

Simple diffusion is the movement of molecules from an area of higher concentration to an area of lower concentration without the need for energy or a transport protein. This process is typically used by small, non-polar molecules such as:

  • Oxygen (O2)
  • Carbon dioxide (CO2)
  • Lipid-soluble molecules (e.g., steroids)

Facilitated Diffusion

Facilitated diffusion also involves the movement of molecules from an area of higher concentration to an area of lower concentration, but it requires the assistance of transport proteins. This method is used by larger or polar molecules that cannot easily pass through the lipid bilayer, such as:

  • Glucose
  • Amino acids
  • Ions (e.g., Na+, K+, Cl)

Active Transport

Active transport moves molecules against their concentration gradient, from an area of lower concentration to an area of higher concentration. This process requires energy, usually in the form of ATP, and involves specific transport proteins. Active transport is used for:

  • Ions (e.g., Na+, K+, Ca2+)
  • Large molecules (e.g., proteins)
  • Nutrients that need to be concentrated inside the cell

Understanding these mechanisms helps explain how cells maintain homeostasis and regulate the movement of essential molecules.

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