The primary theme of Fever 1793 revolves around survival and the struggle against adversity. Set against the backdrop of the yellow fever epidemic that ravaged Philadelphia in the late 18th century, the novel explores how characters confront fear, loss, and the fight for life.
Another significant theme is the impact of societal change. The story illustrates how a crisis can alter the dynamics of a community, testing the bonds of family and friendships while also revealing the resilience and courage individuals can exhibit during times of hardship.
Additionally, the theme of growth and coming of age is prominent, especially through the eyes of the protagonist, Matilda Cook. As she faces the realities of disease and loss, she transitions from the sheltered life of a young girl to a more mature individual who learns important life lessons about responsibility, compassion, and the importance of caring for others in a time of crisis.