Macbeth is killed by Macduff in the final act of Shakespeare’s play ‘Macbeth.’ After a series of prophecies and manipulations, Macbeth becomes the King of Scotland but is plagued by guilt and paranoia. In the end, Macduff, who was born via a Caesarean section and thus not ‘of woman born’ as per the witches’ prophecy, confronts Macbeth. They engage in a fierce battle, and Macduff ultimately beheads Macbeth, fulfilling the prophecy and ending Macbeth’s tyrannical rule.