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English Lexicon

Gene cluster

/ˈdʒiːn ˈklʌs.tər/
nounCEFR C1 (Advanced)Top #28400 frequency
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Comprehensive Definitions & Senses

2 senses
As noun
  1. 1

    A group of two or more genes found within an organism's DNA that encode similar polypeptides or proteins, likely resulting from the duplication of a single original gene.

    "The beta-globin gene cluster contains multiple genes that are expressed at different stages of human development."
  2. 2

    A set of adjacent genes that encode different enzymes involved in a single metabolic pathway.

    "In bacteria, biosynthetic gene clusters are often transcribed together as an operon to produce secondary metabolites."
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Antonyms & Contrasting Words (1)

Linguistic Origin & Historical Etymology

The term is a modern scientific compound combining 'gene', derived from the German 'Gen' and rooted in the Greek 'genos' (birth, race, offspring), with 'cluster', originating from Middle English roots related to a bunch or clump. It emerged in molecular biology during the mid-20th century as genetic mapping revealed groups of duplicated or functionally related genes positioned closely together on a chromosome.

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