A nucleotide is the basic building block of DNA and RNA, and it consists of three main components:
- Phosphate Group: This is a molecule that contains a phosphorus atom bonded to four oxygen atoms. In the backbone of DNA, the phosphate groups link together the sugar molecules.
- Deoxyribose Sugar: In DNA, the sugar is deoxyribose, a five-carbon sugar molecule. This sugar molecule connects to the phosphate group and the nitrogenous base.
- Nitrogenous Base: This component can be one of four types in DNA: adenine (A), thymine (T), cytosine (C), or guanine (G). The specific sequence of these bases encodes genetic information.
In a strand of DNA, nucleotides are formed through a process called dehydration synthesis or condensation reaction. During this process, the hydroxyl group (-OH) from the sugar of one nucleotide reacts with the hydrogen atom (-H) of the phosphate group of another nucleotide, resulting in the release of a water molecule (H2O) and the formation of a phosphodiester bond. This bond links the nucleotides together in a long chain, creating the backbone of the DNA helix, while the nitrogenous bases extend from this backbone, forming the rungs of the DNA ladder.