The first European known to explore the Mississippi River was Spanish explorer Hernando de Soto. He arrived in what is now the United States in 1539, and during his expedition, he traveled through parts of the southeastern region of North America. In 1541, De Soto and his men became the first Europeans to reach the Mississippi River, which they crossed near present-day Memphis, Tennessee.
De Soto’s exploration of the Mississippi was significant, as it opened up further opportunities for exploration and colonization of the interior of North America. His journey contributed to the broader Spanish interest in the continent and its resources, although it was fraught with challenges and conflicts with indigenous populations.
Despite the hardships he faced, De Soto’s expedition provided valuable information about the geography and native cultures of the region, even though it did not lead to permanent Spanish settlements along the river at that time.