If nuclear pores were blocked, the creation of ribosomes would be severely impacted. Ribosome synthesis occurs in the nucleolus, a dense region within the nucleus where ribosomal RNA (rRNA) is transcribed and combined with proteins to form the ribosomal subunits. These subunits then need to be transported out of the nucleus and into the cytoplasm through the nuclear pores.
When the nuclear pores are blocked, the essential transfer of ribosomal subunits is hindered. This blockage means that although rRNA and proteins may still be produced, the fully assembled ribosomal subunits cannot exit the nucleus to participate in protein synthesis in the cytoplasm.
As a result, protein synthesis would be disrupted, which could affect various cellular functions. Over time, the accumulation of unutilized ribosomal subunits might lead to an imbalance in cellular homeostasis, impacting cell growth and function significantly.