The result of multiplying 4 by 16 is 64. This is because when you add 4 sixteen times (4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4), the total sum comes out to be 64. Multiplication is essentially a shortcut for repeated addition, making it easier to calculate larger numbers.