When cells are damaged, they release various chemical mediators, such as histamines, prostaglandins, and cytokines. These substances play a crucial role in the body’s inflammatory response. One of the primary effects of these mediators is to cause capillaries to dilate, which increases blood flow to the affected area.
This increased blood flow is what leads to the classic signs of inflammation: redness, warmth, and swelling of the skin. As more blood rushes to the site of injury, immune cells, such as macrophages and dendritic cells, are also recruited to the area. These cells release additional signals that can stimulate the production of more mediators, perpetuating the inflammatory process and helping the body to repair itself.
In summary, the release of chemical mediators by damaged cells is a key initial step in the inflammatory response, promoting increased blood flow and bringing immune cells to the site of damage.