Identify the Functional Groups in Aspirin, Ibuprofen, and Acetaminophen. How Are These Compounds Similar?

Aspirin, ibuprofen, and acetaminophen are widely used medications, each with distinct chemical structures, but they also share some similarities.

Aspirin (acetylsalicylic acid) contains the following functional groups:

  • Carboxylic acid group (−COOH): This group is responsible for some of the drug’s anti-inflammatory properties.
  • Ester group (−COO−): Acetylation of the salicylic acid creates this functional group, which helps in modulating its reactivity and bioactivity.

Ibuprofen contains:

  • Carboxylic acid group (−COOH): Similar to aspirin, it contributes to the anti-inflammatory effects.
  • Propanoic acid derivatives: This reveals its structure as a non-steroidal anti-inflammatory drug (NSAID).

Acetaminophen (paracetamol) has:

  • Hydroxyl group (−OH): This group is involved in its analgesic and antipyretic properties.
  • Amide group (−NH−): This influences its solubility and metabolic pathways.

Similarities:

  • All three compounds contain functional groups that contribute to their analgesic (pain-relieving) and anti-inflammatory properties.
  • They are used to treat pain and fever, showcasing their role as common over-the-counter medications.
  • Each compound interacts with the cyclooxygenase (COX) enzymes in the body, which play a key role in the inflammation pathway.

In summary, while aspirin, ibuprofen, and acetaminophen have distinct functional groups, their shared characteristics allow them to effectively alleviate discomfort and reduce inflammation.

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