James V of Scotland was the nephew of Henry VIII of England. This relationship was established through James V’s mother, Margaret Tudor, who was the sister of Henry VIII. Margaret Tudor married James IV of Scotland, making James V their son and thus the nephew of Henry VIII.
This familial connection played a significant role in the political dynamics between England and Scotland during their reigns. Despite their family ties, the relationship between James V and Henry VIII was often strained due to political and religious differences.