No, a two-way radio generally cannot communicate directly with a CB radio.
This limitation primarily arises from the difference in frequency bands and modulation types used by these devices. Two-way radios often operate on VHF (Very High Frequency) or UHF (Ultra High Frequency) bands, whereas CB radios operate specifically on 27 MHz, which falls within the HF (High Frequency) range.
Furthermore, two-way radios commonly utilize FM (Frequency Modulation), while CB radios predominantly use AM (Amplitude Modulation). These fundamental variations in technology and frequency prevent the two devices from being compatible for direct communication.
However, there are some creative workarounds that enthusiasts might engage in, such as using repeaters or gateways, but this typically involves additional equipment and is not a straightforward solution. In normal circumstances, if you aim to communicate, you need both parties to use the same type of radio system.