Definition, Meaning & Synonyms

protonation

noun

/ˌprəʊtəˈneɪʃən/

Definition

The addition of a proton (H⁺) to a molecule, resulting in a positively charged ion or a change in the chemical properties of the molecule.

Examples

The protonation of ammonia in water results in the formation of ammonium ions.
In organic chemistry, protonation often alters the reaction pathway of a substrate.
The protonation state of a molecule can significantly affect its solubility and biological activity.

Meaning

Protonation is a fundamental chemical process that occurs in acids and bases, where an acidic substance donates a proton to a base, thus enhancing its reactivity.