Definition, Meaning & Synonyms
orthosteric
Adjective
/ɔrˈθoʊstɛrɪk/
Definition
Relating to the part of a receptor that binds the main ligand, as opposed to allosteric sites.
Examples
- The orthosteric binding site of the receptor is essential for drug activity.
- This compound acts on the orthosteric site to produce its effects on the nervous system.
Meaning
Orthosteric refers to the primary location on a receptor where a substance, like a neurotransmitter or hormone, attaches to initiate a biological response.
Synonyms
- Primary binding site
- Main ligand-binding site
