Definition, Meaning & Synonyms
downregulation
noun
/daʊnˌrɛɡjʊˈleɪʃən/
Definition
The process by which a cell reduces the quantity or activity of a specific cellular component, such as a receptor, in response to various stimuli.
Examples
- Downregulation of receptors can occur after prolonged exposure to a high concentration of a hormone.
- In some diseases, downregulation of immune receptors can lead to decreased immune responses.
- Researchers are studying the effects of downregulation on cancer cells and their growth.
Meaning
Downregulation typically refers to the decreases in the level of receptor expression on the cell surface, affecting cellular response to stimuli.
Synonyms
- decrease
- reduction
- suppression
