Definition, Meaning & Synonyms

constitutive-activation

noun

/ˈkɒn.stɪ.tʃuː.tɪv ˌæk.tɪˈveɪ.ʃən/

Definition

Constitutive activation refers to the continuous or inherent activation of a cellular receptor or protein, without the need for an external stimulus or ligand. This can occur due to mutations or alterations in the structure of the receptor or protein.

Examples

Constitutive activation of the receptor can lead to uncontrolled cell growth.
In certain cancers, mutations may cause constitutive-activation of signaling pathways involved in cell proliferation.
Researchers are studying the effects of constitutive activation on various physiological conditions.

Meaning

In biological contexts, constitutive activation commonly describes situations where a receptor is active in the absence of its usual activating ligand, leading to ongoing signaling processes that can affect cellular function and behavior.