A Woman Who is Heterozygous for Hemophilia Marries a Normal Male: What Are the Possible Phenotypes of Their Children?

To understand the possible phenotypes of the children in this scenario, we first need to look at the genetics of hemophilia. Hemophilia is a X-linked recessive disorder, which means that the gene responsible for hemophilia is located on the X chromosome. A woman who is heterozygous for hemophilia has one normal X chromosome (X^N) and one affected X chromosome (X^h), while the normal male has one normal X chromosome (X^N) and one Y chromosome (Y).

When they have children, the mother (X^NX^h) can pass on either her normal X chromosome (X^N) or her affected X chromosome (X^h). The father (X^NY) can pass on his normal X chromosome (X^N) to daughters or his Y chromosome (Y) to sons.

The possible combinations for their children would be:

• Daughters: X^NX^N (normal phenotype) or X^NX^h (carrier but normal phenotype)
• Sons: X^NY (normal phenotype) or X^hY (hemophilia)

In summary, the children could have the following phenotypes:

• Normal daughters
• Carrier daughters
• Normal sons
• Hemophiliac sons

This results in a combination of normal and affected phenotypes among the children, highlighting the role of X-linked inheritance in the transmission of hemophilia.