No, Florence Nightingale did not have any children.
Florence was deeply committed to her work in nursing and healthcare reform, dedicating her life to her profession and the betterment of medical practices. Despite being engaged to a man named Richard Monckton Milnes, she never married. Florence was known for her strong independence and often focused on her career rather than personal relationships. This commitment meant that she did not take on the traditional roles of wife and mother, which were expected during her time.