Sam Shepard was diagnosed with ALS (Amyotrophic Lateral Sclerosis) in 2015. ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Shepard kept his diagnosis private and continued to work on his projects until his passing in 2017. His battle with ALS brought attention to the disease and the need for more research and support for those affected.